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The broad goal of the work carried out in our laboratory is to understand how the mammalian nervous system controls the action of skeletal muscles to produce coordinated movements. We use a variety of experimental approaches, including computer modeling and simulation, single motor unit recording, and microneurographic methods to record and stimulate single sensory and motor axons. Our experiments address a range of topics from those related to how individual neurons integrate synaptic information to those associated with the development of new methods to restore movement and sensation in paralyzed individuals. Of particular emphasis at present are studies designed to characterize the functional organization of the corticospinal pathways that underlie the control of hand and finger movements.
Awards and Honors
Member, Musculoskeletal & Rehabilitation Sciences Study Section, NIH (2007 - 2011)Grant Support
The work in this lab is supported by grants from the National Institute of Neurological Disorders and Stroke (NS 39489) and from BIO5.Biomedical Engineering
Neuroscience
Physiological Sciences
McIsaac TL, Fuglevand AJ. May 2008. Common synaptic input across motor nuclei supplying intrinsic muscles involved in the precision grip. Exp Brain Res,2008 May 28;
Anderson CV, Fuglevand AJ. Apr 2008. Probability-Based Prediction Of Activity In Multiple Arm Muscles: Implications For Functional Electrical Stimulation. J Neurophysiol,2008 Apr 24;
McIsaac TL, Fuglevand AJ. Nov 2006. Motor unit synchrony within and across compartments of the human flexor digitorum superficialis. J Neurophysiol,2006 Nov 8;
Bailey EF, Rice AD, Fuglevand AJ. Oct 2006. Firing patterns of human genioglossus motor units during voluntary tongue movements. J Neurophysiol,2006 Oct 4;
McIsaac TL, Fuglevand AJ. Sep 2006. Influence of tactile afferents on the coordination of muscles during a simulated precision grip. Exp Brain Res,2006 Sep 19;
Waller BM, Vick SJ, Parr LA, Bard KA, Pasqualini MC, Gothard KM, Fuglevand AJ. Aug 2006. Intramuscular electrical stimulation of facial muscles in humans and chimpanzees: duchenne revisited and extended. Emotion, 6:367-82
Fuglevand AJ, Dutoit AP, Johns RK, Keen DA. Mar 2006. Evaluation of plateau-potential-mediated 'warm up' in human motor units. J Physiol, 571:683-93
Hockensmith GB, Lowell SY, Fuglevand AJ. May 2005. Common input across motor nuclei mediating precision grip in humans. J Neurosci, 25:4560-4
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