The University of Arizona

Department of Physiology - The University of Arizona

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Faculty

Nicholas Delamere

Department Head & Professor

Contact Information

Address: P.O. Box 245051

Phone: (520) 626-6425
Email: delamere@arizona.edu


Website:

Research Interests

After receiving his doctorate at the University of East Anglia in his native England, Nicholas Delamere brought his work on membrane transport physiology to the University of Colorado, where he spent ten years. He moved to the University of Louisville in 1986 where he established a laboratory to study the mechanisms which control ocular pressure, fluid movement and the regulation of ion transport molecules in lens and optic nerve. In 2006, together with several lab members, he joined the University of Arizona.


In essence, Dr. Delamere examines the manner in which cells transport salt and water. Too much fluid (aqueous humor) secreted into the eye can increase pressure within the eye, leading to glaucoma and retinal damage. Dr. Delamere's research team seeks to regulate these transport mechanisms on the molecular level, with the eventual goal of developing drugs to maintain this intraocular balance and reduce the incidence of glaucoma.


In another area of research, Dr. Delamere tackles the problem of age-related cataracts and how they can be affected by regulating the activity of the membrane transport pump Na,K-ATPase. Since human lenses contain the same cells from conception to death, with no tissue regeneration or loss, this area of research offers a promising model for tissue preservation, anti-aging constructs and neuroprotection in the brain. Reducing the onset of cataracts through membrane transport physiology, even for a few more years, would result in huge savings of cost, effort and anxiety.

Graduate Program Affiliations

Physiological Sciences

Publications

Khundmiri, S.J., Amin, V., Henson, J., Lewis, J., Ameen, M., Rane, M.J. and Delamere, N.A.. Ouabain stimulates Protein Kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway. Am. J. Physiol. (Cell),, in press.

Shigeo Tamiya, Mansim C. Okafor, and Nicholas A. Delamere. Aug 2007. Purinergic agonists stimulate lens Na-K-ATPase-mediated transport via a Src tyrosine kinase-dependent pathway. Am J Physiol Cell Physiol, 293:C790-C796

Mohammed Shahidullah, Shigeo Tamiya, and Nicholas A. Delamere. Jul 2007. Primary Culture of Porcine Nonpigmented Ciliary Epithelium. Current Eye Research, 32:511-522

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