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Department of Physiology - The University of Arizona

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Patricia Hoyer

Professor

Contact Information

Address: P.O. Box 245051
Tucson, AZ 85724
Phone: (520) 626-6688
Email: hoyer@u.arizona.edu


Website: http://www.physiology.arizona.edu/index.php/articles/46

Research Interests

  •  Elucidating signaling pathways that regulate cell death by apoptosis
  • Establishing mechanisms of ovotoxicity caused by environmental chemicals
  •  Developing models that alter the rate of atresia in ovarian follicles
  • Characterizing a chemically-induced follicle-depleted ovary-intact rodent for peri- and post- menopause

Curriculum Vitae

A.  Positions and Honors.

PROFESSIONAL EXPERIENCE:
8/64 - 6/65 MT-ASCP, Medical technologist/instructor - Department of Pathology, College of   Medicine, University of Nebraska
9/69 - 9/71 MT-ASCP, Medical technologist, GS-7, Special Chemistry, Fitzsimons General Army   Hospital, Denver, Colorado
9/76 - 5/78 Graduate Teaching Assistant, College of Pharmacy, University of Wyoming
5/78 - 7/81 Graduate Teaching Assistant, Department of Biochemistry, University of Wyoming
7/81 - 8/84 NIH Postdoctoral Fellow, Department of Physiology and Biophysics, Colorado State   University
8/84 - 4/90 Assistant Professor, Department of Physiology, College of Medicine, University of   Arizona
4/90 - 7/96 Associate Professor, Department of Physiology, College of Medicine, University of
  Arizona
7/91- 7/96          Adjunct Associate Professor, Department of Animal Sciences, University of Arizona
4/93 - present Investigator, Center for Toxicology, University of Arizona
4/93 - present Investigator, Southwest Environmental Health Sciences Center
7/96 - present Professor, Department of Physiology, College of Medicine, University of Arizona
7/96 - present Adjunct Professor, Department of Animal Sciences, University of Arizona
7/01 - present Adjunct Professor, Department of Pharmacology and Toxicology, University of Arizona

SOCIETIES AND HONORS: (selected)
NIH Postdoctoral Awardee HD06254 (1981-1984)
NIH Career Development Awardee HD00907 (1991-1996)
Personnel B Scientific Advisory Committee - American Cancer Society - (1992 - 1996); Chairman 1996
Member - Reproductive Endocrinology Study Section - National Institutes of Health (1995 – 1999); Chairman 2002-2004
President - Mountain West Society of Toxicology (1999 - 2000)
Editorial Board - Biology of Reproduction (1995-1999; 2001-2007)
Associate Editor - Toxicology and Applied Pharmacology (2001-2006)
Founders’ Day Award – College of Medicine, University of Arizona (2002)
Editorial Board – Reproduction and Developmental Toxicology Journal (2003-present)
Board of Directors – Society for Study of Reproduction (2003-2006)
Organizing Board - Serono Ovarian Workshop (2003-2009)
Editorial Board – Endocrinology (2004-2007)

B. Selected recent  peer-reviewed publications (in chronological order)

Hu, X, Christian, P.J., Flaws, J.A., Sipes, I.G., Hoyer, P.B. 2002 Activation of mitogen-activated protein kinases and AP-1 transcription factor in ovovtoxicity induced by 4-vinylcyclohexene diepoxide in rats.  Biol. Reprod. 67:718-724.

Cannady, E.A., Sipes, I.G., Hoyer, P.B. 2002 Expression and activity of microsomal epoxide hydrolase in isolated mouse ovarian follicles. Toxicol. Sci. 68:24-31.

Devine, P.J., Sipes, I.G., Skinner, M.K., Hoyer, P.B. 2002 Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide.  Toxicol. Appl. Pharmacol. 184:107-115 .

Mayer, L.P., Pearsall, N.A. Christian, P.J., Devine, P.J., Payne, C.M., Mccuskey, M.K., Marion, S.L., Sipes, I.G., Hoyer, P.B. 2002 Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide. Reprod. Toxciol. 16(6):775-781.

Cannady, E.A., Dyer, C.A., Christian, P.J., Sipes, I.G., Hoyer, P.B. 2003  Expression and activity of cytochromes P450 2E1, 2A and 2B in the mouse ovary:  The effect of dosing with 4-vinylcyclohexene and its diepoxide metabolite. Toxicol. Sci. 73(2):423-430.

Mayer, L.P., Devine, P.J., Dyer, C.A., Hoyer, P.B. 2004 The follicle-depleted mouse ovary produces androgen.  Biol. Reprod. 71:130-138.

Devine, P.J., Sipes, I.G., Hoyer, P.B. 2004 Initiation of delayed ovotoxicity by in vitro and in vivo exposures of rat ovaries to 4-vinylcyclohexened diepoxide.  Reprod. Toxicol. 19:71-77.

Thompson, K.E., Bourguet, S.M., Christian, P.J., Benedict, J.M., Flaws, J.A., Sipes, I.G., Hoyer, P.B.  Differences between rats and mice in the role of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss (In Press, Toxicol. Appl. Pharmacol.).

Graduate Program Affiliations

Animal Sciences

Pharmacology & Toxicology

Physiological Sciences

Publications

Appt SE Kaplan JR Clarkson TB Cline JM Christian PJ Hoyer PB. Oct 2006. Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition. Fertil Steril, 86 Suppl 4:1210-6

Rozman KK Bhatia J Calafat AM Chambers C Culty M Etzel RA Flaws JA Hansen DK Hoyer PB Jeffery EH Kesner JS Marty S Thomas JA Umbach D. Aug 2006. NTP-CERHR expert panel report on the reproductive and developmental toxicity of soy formula. Birth Defects Res B Dev Reprod Toxicol, 77:280-397

Kanter EM Walker RM Marion SL Brewer M Hoyer PB Barton JK. Jul 2006. Dual modality imaging of a novel rat model of ovarian carcinogenesis. J Biomed Opt, 11:041123

Lohff JC Christian PJ Marion SL Hoyer PB. May 2006. Effect of duration of dosing on onset of ovarian failure in a chemical-induced mouse model of perimenopause. Menopause, 13:482-8

Flaws JA, Marion SL, Miller KP, Christian PJ, Babus JK, Hoyer PB. Apr 2006. Effect of bcl-2 overexpression in mice on ovotoxicity caused by 4-vinylcyclohexene. Toxicol Appl Pharmacol,2006 Apr 20;

Lohff JC, Christian PJ, Marion SL, Arrandale A, Hoyer PB. Dec 2005. Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause. Comp Med, 55:523-7

Mayer LP, Dyer CA, Eastgard RL, Hoyer PB, Banka CL. Sep 2005. Atherosclerotic lesion development in a novel ovary-intact mouse model of perimenopause. Arterioscler Thromb Vasc Biol, 25:1910-6

Hoyer PB. Apr 2005. Damage to ovarian development and function. Cell Tissue Res,2005 Apr 23;

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