The University of Arizona

Department of Physiology - The University of Arizona

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Faculty

Ronald Lynch

Professor

Contact Information

Address: P.O. Box 245051
Tucson, AZ 85724
Phone: (520) 626-2472
Email: rlynch@u.arizona.edu


Website: http://www.physiology.arizona.edu/labs/llab/Lynch.html

Research Interests

Research in the Lynch lab primarily focuses on second messenger signaling in vascular smooth muscle cells and nutrient sensing hypothalamic neurons with emphasis on alterations in signaling that occur during development of diabetes.   Alterations in Ca2+ homeostasis and contractility are observed in vascular cells in association with the elevated levels of glucose and insulin that occur during development of type II diabetes. To study these issues, cells isolated from transgenic animals in which specific genes for Ca2+ handling are ablated or over-expressed are utilized as model systems.  Analysis of subcellular protein distributions and second messenger signaling is performed in our lab using state of the art image acquisition and analysis approaches which is our second area of expertise. Over the past decade, our lab has been involved in the development of unique microscopic imaging and spectroscopy approaches to study cell and tissue function. As part of this effort, we have developed, with collaborators, methods for targeting specific cell types in mice for in situ identification and rapid isolation. Using this approach, analysis of cell-type specific gene expression and function can be performed.

Laboratory website

http://www.physiology.arizona.edu/labs/llab/Lynch.html

Graduate Program Affiliations

Biomedical Engineering

Biomedical Imaging and Spectroscopy

Physiological Sciences

Publications

Xu, H. H. Chen, J. Dong, R.M. Lynch and F.K. Ghishan. Apr 2008. The Distribution of NHE8 in the gastrointestinal. Cell. Physiol. Biochem., 21:109-116

Scriven DR, Lynch RM, Moore ED. Mar 2008. Image Acquisition for Colocalization Using Optical Microscopy. Am J Physiol Cell Physiol, 294:C1119-22

Lynch RM, Weber CS, Nullmeyer KD, Moore ED, Paul RJ. Mar 2008. Clearance of store-released Ca2+ by the Na+-Ca2+ exchanger is diminished in aortic smooth muscle from Na+-K+-ATPase {alpha}2-isoform gene-ablated mice. Am J Physiol Heart Circ Physiol, 294:H1407-16

Barthelson RA, Lambert GM, Vanier C, Lynch RM, Galbraith DW. Sep 2007. Comparison of the contributions of the nuclear and cytoplasmic compartments to global gene expression in human cells. BMC Genomics, 8:340-347

Pritchard TJ, Bullard DP, Lynch RM, Lorenz JN, Paul RJ.. Aug 2007. Transgenic Mice Expressing Na+-K+ ATPase in Smooth Muscle Decreases Blood Pressure.. Am J Physiol Heart Circ Physiol. 2007, 293(2):H1172-82

Zhou, M., E. Nakatani, L.S. Gronenberg, T. Tokimoto, M.J. Wirth, V.J. Hruby, A. Roberts, R.M. Lynch, and I. Ghosh. Feb 2007. Peptide Labeled Quantum Dots for Imaging GPCRs in Whole Cells and as Single Molecules. Bioconjugate Chem., 18:323-329

Xu L, Dixit MP, Nullmeyer KD, Xu H, Kiela PR, Lynch RM, Ghishan FK. Mar 2006. Regulation of Na(+)/H(+) exchanger-NHE3 by angiotensin-II in OKP cells. Biochim Biophys Acta, 1758:519-526

Martinez-Zaguilan R, Tompkins LS, Gillies RJ, Lynch RM. Jan 2006. Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Mol Biol, 312:269-87

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