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Microcirculation Division, History
The In 1979, Drs. Johnson and Gross received approval from the State
legislature to create a faculty position for the interdisciplinary area of
theoretical microcirculation, leading to the appointment of Timothy W. Secomb
in 1981 as a member of the Arizona
Research Laboratories, with joint appointments in Physiology and
Mathematics. The reorganization of the Arizona Research Laboratories in 1983 led to the
creation of the Microcirculation Division, directed by Dr. Gross. In 1989,
the Division moved into a University-owned house at
The mission of the Microcirculation Division is to provide
interdisciplinary research and educational programs, in which engineering and
mathematical approaches are applied in physiology and other health sciences.
The focus of research is on physiological transport, especially in the microcirculation,
in normal and pathological conditions. Teaching activities include offering
undergraduate and graduate courses and training graduate and postdoctoral
students in the areas described above. This unique interdisciplinary focus of
the Microcirculation Division builds on and enhances major strengths of the Current personnel
Timothy W. Secomb,
Ph.D., Professor and Director Jonathan Alberding, Ph.D.,
Research Associate Julia Arciero, Graduate Student
in Applied Mathematics Jared Barber, Graduate Student in
Applied Mathematics Ardith El-Kareh, Ph.D., Research
Associate Professor Denise Ravenwood, Administrative
Assistant Current research projects and
collaborations
Current funding sources
National Institutes of Health, National Heart Lung and Blood Institute Selected recent publications ·
Gruionu, G., Hoying,
J.B., Pries, A.R.. and Secomb, T.W.
Structural remodeling of the mouse gracilis artery following chronic
alteration in blood supply. Am.
J. Physiol., 288: H2047-2054 (2005). ·
Carlson, B.E. and
Secomb, T.W. A theoretical model for the myogenic response based on the
mechanics of vascular smooth muscle.
Microcirculation, 12: 327-338 (2005). ·
Gruionu, G., Hoying,
J.B., Gruionu, L.G., Laughlin, M.H. and Secomb, T.W. Structural adaptation increases
predicted perfusion capacity following vessel obstruction in the arteriolar
arcade network of pig skeletal muscle.
Am. J. Physiol., 288: H2778-2784 (2005). ·
El-Kareh, A.W. and
Secomb, T.W. Two mechanism peak
concentration model for cellular pharmacodynamics of doxorubicin. Neoplasia, 7: 705-713 (2005). ·
Pries, A.R., Reglin,
B. and Secomb, T.W. Remodeling of
blood vessels: responses of diameter and wall thickness to hemodynamic and
metabolic stimuli. Hypertension, 46: 725-731 (2005). See commentary: Modeling the vasculature: A judicious
approach? by M.J. Mulvany. Hypertension 46:652-653 (2005). ·
Pries, A.R. and
Secomb, T.W. Microvascular blood
viscosity in vivo and the endothelial surface layer. Am. J. Physiol., 289: H2657-H2664
(2005). ·
Lanzen, J., Braun,
R.D., Klitzman, B., Brizel, D., Secomb, T.W., Dewhirst, M.W. Direct demonstration of instabilities
in oxygen concentrations within the extravascular compartment of an
experimental tumor. Cancer
Research, 66: 2219-2223 (2006). ·
Hicks, K.O, Pruijn,
F.B., Secomb, T.W., Hay, M.P., Hsu, R., Brown, J.M., Denny, W.A., Dewhirst,
M.W., ·
Skotheim, J.M. and
Secomb, T.W. Red blood cells and
other non spherical capsules in shear flow: oscillatory dynamics and the tank
treading to tumbling transition.
Physical Rev. Letters 98: 078301 (4 pp.) (2007). ·
Cardenas-Navia,
L.I., Secomb, T.W. and Dewhirst, M.W. Effects of fluctuating oxygenation on
tirapazamine efficacy: Theoretical predictions. International Journal of
Radiation Oncology, Biology, Physics 67: 581-6 (2007). ·
Secomb, T.W.,
Styp-Rekowska, B. and Pries, A.R. Simulation of red blood cell deformation
and lateral migration in microvessels.
Annals of Biomedical Engineering 35: 755-765 (2007). ·
Styp Rekowska, B.,
Mecha Disassa, N., Reglin, B., ·
Goriely, A.R., ·
Barber, B.J.,
Donnerstein R.L., Secomb, T.W., Pogreba-Brown, K., Steelman, R., Ellenby,
M.S., Shen, Updated 14 August, 2007 |
