Samantha Harris, PhD 

Professor, Physiology
Professor, Physiological Sciences - GIDP
Professor BIO5 Institute
Professor Biomedical Engineering
Research Interests

The primary research interest of my lab is to understand the role of myosin binding protein-C (MyBPC) in the regulation of striated muscle contraction and how mutations in the 3 distinct genes encoding MyBP- C cause diseases in cardiac and skeletal muscles. To study MyBP-C my lab uses a wide variety of approaches ranging from single molecule biophysical and biochemical methods to whole animal models of disease. Methods include atomic force microscopy, biochemical binding and motility assays, ex vivo force measurements in permeabilized contracting muscle, and measurement of whole heart cardiac function in engineered rodent models of disease and in a naturally occurring feline model of HCM with a genetic mutation in cMyBP-C. More recently my lab has pioneered an entirely new approach (a patented “cut and paste” method) for replacing cMyBP-C in cardiac sarcomeres in situ in permeabilized myocytes from gene-edited “Spy-C3” mice.


  • 1998 BS Biology - University of Illinois
  • 1995 PhD Physiology - University of Michigan
  • 2001 Post-doctoral - University of Wisconsin
Publication Highlights

Napierski NC, Granger K, Langlais PR, Moran HR, Strom J, Touma K, Harris SP. A Novel "Cut and Paste"Method for In Situ Replacement of cMyBP-C Reveals a New Role for cMyBP-C in the Regulation ofContractile Oscillations. Circ Res. 2020 Mar 13;126(6):737-749. doi:10.1161/CIRCRESAHA.119.315760. Epub 2020 Feb 13. PubMed PMID: 32078438; PubMed Central PMCID:PMC7577522.

Harris SP. Making waves: A proposed new role for myosin-binding protein C in regulating oscillatorycontractions in vertebrate striated muscle. J Gen Physiol. 2021 Mar 1;153(3). doi:10.1085/jgp.202012729. PubMed PMID: 33275758; PubMed Central PMCID: PMC7721898